Greatly thickened corneal nerves and subconjunctival tumors may be the first hint of MEN 2b. Whenever greatly thickened corneal nerves are detected, MEN 2b must be ruled out.

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We determined immunoreactive inhibin (irlNH) concentration in the gonads and adrenals of healthy children (0-75 months) who had died suddenly. Testicular irlNH peaked in the first 3 months of life with a significant drop in the 4th month (p < 0.05). In ovarian tissue, irlNH was significantly lower than in the testes (p < 0.001) with highest levels during the first 4 months of life parallel to the highest estradiol concentrations. A significant correlation between gonadal testosterone/estradiol and irlNH was observed. In adrenal tissue, irlNH levels were significantly lower than in the gonads without sex-specific differences.