In this experimental research, thin polyurethane films containing reactive functional groups (hydroxyl and amino groups) were synthesized. The raw materials used in the synthesis are: a hydroxyl component (Elastoflex W5516/115) and an isocyanate component (semiprepolimer type) based on 4,4'- diphenylmethane-diisocyanate (MDI) or toluene-2,4-diisocyanate (TDI). Two different antibiotics were adsorbed on these films: amikacin and ceftazidime which formed physical bonds with the polyurethane matrix. The films were characterized by SEM, DMA and a culture of Escherichia coli and a counting room was used in order to determine the antimicrobial efficiency.

In industrialized countries, many researches have highlighted a correlation between the presence of octylphenol in different plastics or detergents and its estrogenic effect. The metabolism of alkylphenols (4-n-octylphenol and 4-tert-octylphenol) is depending on alkyl chain and at testicular level act as endocrine disruptions. The purpose of our work was to evaluate the octylphenol effect on the testicular morphological changes in mice. Our experiment was performed on adult mice, divided into three experimental groups of 5 individuals each, respectively: control group (C -untreated); the vehicle group (V) treated with ethanol and corn oil mixt (1:10); and experimental group (E - treated with octylphenol in concentrations of 80 mg / kg body weight). Octylphenol is a pollutant that has to be monitoring because our study showed a decrease in male fertility due to morphological alterations as a result of exposure to a series of hormone mimetic molecules. Animals exposed to octylphenol presented morphological changes at the testicular level manifested disorganization of the seminiferous epithelium, hypertrophic and hypereosinophilic spermatocytes, presence of apoptotic bodies, as well as the diffuse hyperplasia of the Leydig interstitial cells, proving that octylphenol negative influences the male fertility.

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