Gold mineralization of the Upper Lom Basin in the eastern Cameroon goldfield is spatially associated with tourmaline. The goldfield belongs to the Adamawa-Yadé Domain of the Central African Fold Belt and is characterized by eluvial, alluvial and lode gold deposits of Pan-African age. This paper examines the chemistry and morphology of saprock gold and its link with tourmaline in the host rock. Tourmaline chemistry was obtained using the electron microprobe analysis (EMPA) technique while gold grains were examined for morphology and microchemistry using the EMPA equipped with scanning electron microscopy and energy dispersive spectrum instruments. The tourmaline compositional data plot in the dravite field, and belongs to the alkali group showing major element variations that are typical of tourmaline associated with granite-related orogenic gold deposits common along shear zones. Gold alloy composition (Ag, Cu) suggests multiple gold precipitation events due to episodic fluid influx, with a range of 572–1000 gold fineness. We infer that tourmaline development and gold deposition were coeval within the aureole around the pluton and involved reduced hydrothermal fluids with low salinity. The high δ11B in the tourmaline also points to fluid derivation from the Pan African granitic basement widely recognized to be fertile in gold in eastern Cameroon. Tourmaline textural-chemical features such as low Na content and gold microchemistry point to granite-related hydrothermal style of primary gold mineralization, and has implications for exploration as tourmaline-rich rocks in the vicinity of the felsic plutons in the Lom Basin would be optimal target areas for future exploration.