In this contribution,
we report novel palladium-catalyzed carbonylative
cascade approaches to highly functionalized polyheterocyclic structures.
The Pd-catalyzed carbonylative process involves the regioselective
insertion of one to three CO molecules and the sequential ordered
formation of up to eight new bonds (one C–O, two C–C,
five C–N). The exclusive formation of six-membered heterocycles
is elucidated by detailed modeling studies.
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