Vas occlusion and vasectomy for contraception were compared in a prospective, randomized trial comprising 79 patients. No intergroup differences were found in regard to failure rates or local postoperative complications. Scand J Urol Nephroll7Scand J Urol Nephrol Downloaded from informahealthcare.com by QUT Queensland University of Tech on 11/02/14For personal use only.

No abstract

The penetration of lincomycin into normal bone was studied in 10 patients with fracture of the neck of the femur, a separate determination being made of the lincomycin concentration in serum, bone marrow, spongy bone and compact bone. The concentration of lincomycin in bone marrow was found to be at the same level as that in the serum. The concentration in spongy bone amounted in most cases to 50 to 75 percent of the concentration in the serum, whereas the concentration in compact bone varied from 0 to 15 percent of that in the serum.

In normal human subjects multiple dose trial with an initial dose of 400 mg doxycycline and subsequent doses of 200 mg every 24 hours gave average minimum serum concentrations of between 1 and 2 yg doxycyclinelml serum. The average urine concentrations varied between 100 and 200 yg doxycycline/rnl urine, and 42 per cent of the drug administered was excreted in the urine in an active form. The average renal clearance of doxycycline determined over 96 hours was 28 ml/min. In a single dose trial with 200 mg doxycycline, an 8-hour renal clearance of doxycycline was found to be 13 per cent of the creatinine clearance, and the serum half-life period was found to be 11.6 hours. Microbiological assay was used for all determinations of doxycycline in the serum and urine. The in vitro sensitivity of 211 urinary tract pathogens to doxycycline and oxytetracycline was investigated in order to determine the minimum inhibitory concentration (MIC). The strains, which originated from patients with chronic urinary tract infections, were as a whole only slightly sensitive to the two tetracyclines. Compared with oxytetracycline, doxycycline, assessed at the MIC-level, showed a higher bacteriostatic effect in vitro, especially against gram-positive strains. doxycycline: absorption, distribution et excrCtion d'un nouvel antibiotique a large spectre chez I'homme. Schweiz. med. Wschr. 1967,97, 915-923. Kirschbaum, A., J. Kramer & M. A. Garth: Uniform preparation of microbial suspensions for antibiotic assays. Antibiot. and Chemother. 1962, 12, 545-550. Kunin, G . M., A. C. Dornbush & M. W. Finland: The distribution and excretion of four tetracycline analogues in normal males.