Colonic basidiobolomycosis is a life-threatening fungal infection that should be considered a surgical condition. A high index of suspicion including basidiobolomycosis in the differential diagnosis for the acute abdomen with a colonic mass is required for a proper diagnosis. Early aggressive surgical management followed by a prolonged course of itraconazole postoperatively could improve the outcome of the condition.

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Spindle cell carcinoma (SPCC) is a very rare and unique biphasic variant of squamous cell carcinoma (SCC) which is a very rare malignancy of head and neck region.Spindle cell tumours are challenging feature of head and neck pathology because of different types of spindle cell lesions occurring which can be reactive to benign to malignant and very aggressive. We present here two rare cases of SPCC one involving the nasal cavity in a 38 year female and other a very aggressive maxillary sinus tumour in a 60 year male and discuss its differential diagnosis with an emphasis on biphasic tumours of head and neck.