High plant botanical learning in Biology Tadris study program at IAIN Palangka Raya has not used integrated Islamic modules yet, it can be produced an impact on the learning outcomes achievement, there are 43.25% of students have not achieved on mastery learning grade. The purpose of this study was to produce a valid, practical and effective on the Islamic learning module for high plant botanical courses towards students' independence in using the module. This research used Research & Development and developed a method by using the ADDIE model with stages of Analyze, Design, Development, Implementation, and Evaluation. The results of this study indicated that the modules developed are suitable for use in high plant botanical lecture learning obtained from the validity scores of material experts 97.03% with very good or valid categories, design experts obtained 92.11% with good or valid categories, religious experts obtained 94, 14% with a good or valid category. The application based on observations of the implementation of learning modules obtained an average grade of 98.70% with very successful criteria. The value of practicality is obtained from student responses in using the average module percentage of 94.75% with practical criteria. The independence of students learning using questionnaires has obtained an average of 87.70%. The effectiveness of the application of the module is obtained from improving student learning outcomes with the N-Gain value of 0.7 with a high category compared to the control class of the N-Gain 0.2 with a low category