The pandemic triggered by coronavirus disease (COVID-19) invariably questions the health security of people around the globe. It’s also strongly advocates the need for unique health care practice that substantially prevents the infection and practice of controlling the disease transmission. Alternate therapy with viable medications that can adequately strengthen the immune system to enhance the speedy recovery of the patients becomes the need of the hour. Siddha system of medicine is one such versatile practice that emerged before centuries that incorporates the practice of availing potential remedies from herbal and another natural origin. Still, now there is no proper documentary evidence on evaluating the efficacy of Siddha treatment in the clinical management of COVID-19, hence the main objective of the present pilot study is to investigate the potential of Siddha formulations such as Aadathodai kudineer, Thaalisaathi chooranam, Thulasi chooranam, Pavala parpam, Bramaanandha Bairava Maathirai and Thoothuvalai nei in treatment and accelerating the recovery of COVID19 patients. A Study was executed in 25 patients with laboratory- confirmed diagnosis of COVID-19. The Outcome of the present clinical study signifies that treatment with Siddha medicines significantly accelerated recovery of patients by stabilising the immune mechanism which was evidenced by pronouncing declination in CRP (C- reactive protein), neutrophil, lymphocytes, Lactate dehydrogenase (LDH), Creatinine, Serum Albumin and Serum Urea level almost back to the normal. In conclusion therapy with Siddha medicines opened a new gateway in the clinical practice on managing COVID-19 due presence of vital phytotherapeutics that showcase multiple pharmacological activities against risky pathogens like SARS-CoV-2.

Siddha system of medicine is one of the ancient medicines in the AYUSH system of medicines. It described the prevention and cure of disease through the ways of "Naal Ozhukkam" (daily regimen) and "Kaala Ozhukkam” (seasonal regimen). Fasting (Pattini) is one of these practices of Naal Ozhukkam. In 2016, a Japanese man named Mr. Yoshinori Ohsumi got his Noble Prize for finding the mechanism behind autophagy. Fasting is the most efficient method of activating autophagy. This review showed fasting in our Siddha literature and autophagy from Siddhars perspective in preventing non-communicable diseases. In our Siddha literature, it says that the uses of fasting are to rest our digestive organs, remove toxins and waste products from our bodies, and refresh our body cells. Autophagy is the body’s way of eliminating damaged cells in order to regenerate newer, healthier cells. Recent research has indicated roles for autophagy in an increasing number of pathologies, from bacterial and viral infections to cancer, and more recently in neurodegenerative and other age-related diseases. But during their period, Siddhars treat fever and some other diseases by fasting. By this method, they prevent non-communicable diseases. As a result, we must lead the Siddhars' ideas by performing Naal ozhukkam and Kaala Ozhukkam to prevent non-communicable diseases.