Compromised teeth are challenging to the dentist which complicate the treatment plan which affects the long-term prognosis. Maxillary molars showing untreatable endodontic failure, periodontal attachment loss, extensive carious involvement or fractures involving the furcation area are often difficult to manage. Treatment option for such multi-rooted teeth can be root resection, or extraction and prosthetic replacement. Root resection procedure offers an economically viable treatment option for the patients to preserve the natural tooth. This article highlights 2 case reports of root resection in maxillary molar with different etiologies combined with the periodontal approach and prosthetic management with resultant successful oral rehabilitation.