Acne is a common disease of the pilosebaceous units of the skin and topical therapy is recommended for the management of acne with comedolytic, anti-inflammatory agents, along with antimicrobials. However, topical application of these drugs leads to frequent adverse effects and also, there is an emergence of antibiotic resistance by Propionibacterium acnes. Furthermore, systemic antimicrobial usage has been causally associated with various adverse events. No simple recipe for the treatment can be provided. Treatment options vary with the stage and severity of the disease. So now a day's physicians prefer the herboformulations containing Melaleuca alternifoli, Azadirachta indica, Curcuma longa, Piper nigrum, Aloe vera, Citrus bergamia, Santalum album, Rosa centifolia, Carica papaya etc. than the allopathic drugs due to less or no side effects. Perfact gel is herbal formulation contains 5% of Melaleuca alternifoli (Tea tree oil) and Perfact tablet is polyherbal formulations and contains extracts of Azadirachta indica, Curcuma longa, and Piper nigrum, and the study was conducted to evaluate the efficacy and safety of perfect face, Perfect face tablets and both in the management of acne.

Simple, sensitive and accurate UV-spectroscopic methods were developed and validated for simultaneous estimation of aliskiren and amlodipine in tablet formulation using simultaneous equation and first derivative spectroscopic methods. Developed methods include direct estimation of amlodipine at 365nm without any interference, since aliskiren has zero absorbance at this wavelength. Estimation of aliskiren through simultaneous equation was performed at 279 nm, while 236.8 nm were selected as zero crossing point for estimation of aliskiren by first order derivative spectroscopic method. Linearity was found to be satisfactory over the concentration range of 25-300μg/ml and 5-100μg/ml for aliskiren and amlodipine respectively. The mean percentage label claim of aliskiren and amlodipine using simultaneous equation was 99.84 and 99.85 % respectively, while for first derivative spectroscopic method it was found to be 100.36 and 99.85% respectively. The developed methods are economical and reproducible for routine analysis of aliskiren and amlodipine in tablet formulation.

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Background: Quality of life plays an important role in patients of epilepsy and is the most neglected part during management. The antiepileptic drugs treatment results in seizure control but adversely affect the quality of life in patients on drugs taken for the treatment of epilepsy An observational analytical study was conducted in the Department of pharmacology withMethods: Department of Neurology of Himalayan Institute of Medical Sciences, Dehradun over one year. Total of 120 patients fullling the inclusion criteria with diagnosis of epilepsy were enrolled and divided into two groups based on physicians discretion . Group A were on the conventional antiepileptic drugs , group B received the newer antiepileptic drugs and followed up for 12 weeks. Patients were evaluated for quality of life by QOLIE-10 questionnaire at baseline and 12 weeks, assessed for seizure control and drug related adverse effects. There was signicantResults: improvement in quality of life, in both the groups as compared to baseline (p<0.05) at 12 weeks but there was not signicant change in quality of life in conventional and newer groups. The patients who reported total seizure freedom at 6 weeks was 93% and 90% for older and newer groups respectively .Both groups achieved complete seizure control at 12 weeks. Adverse events reported in patients on conventional groups were more as compared to newer group. Quality of life improved in both group of patients on newer and conventional antiepileptic drugs, withConclusions: similar seizure control but decreased number of adverse effect of newer than on conventional antiepileptic drugs .