Background: Skin aging involves UVB-induced degeneration of the dermal extracellular matrix. Results: Estrogen induces epidermal growth factor expression in keratinocytes thereby stimulating hyaluronan synthase 3 and versican expression in dermal fibroblasts of UVB-irradiated skin. Conclusion: Paracrine release of epidermal growth factor in response to estrogen maintains hyaluronan and versican-rich extracellular matrix. Significance: Estrogen prevents specific aging responses in the hyaluronan matrix of photoaged skin.

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