As part of the ESA/ESOC study "Linux & Multi Core Processor Technology for Simulators" [7], several concepts concerning performance optimization of SIMULUS based operational simulators were introduced. Starting from the possibility to explore parallelism and distributed execution of computational loads (PDES approach) and continuing with the profiling, analysis and focused optimization of specific simulation models our efforts and ideas converged to a Performance Optimization Framework (POF). The present paper summarizes the way the idea of a Performance Optimization Framework can be applied in future operational simulators.