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Purpose The diurnal efficacy and safety of the fixed combinations of latanoprost/timolol given once daily vs dorzolamide/timolol given twice daily in primary open-angle glaucoma or ocular hypertensive patients. Design A double-masked, two-centre, crossover comparison. Results In 33 patients, the mean diurnal IOP (0800-2000, measured every 2 h) for latanoprost/ timolol fixed combination was 17.372.2 mmHg and for dorzolamide/timolol, the fixed combination was 17.072.0 mmHg (P ¼ 0.36). Additionally, there was no statistical difference for individual time points following a Bonferroni correction. A bitter taste was found more frequently with the dorzolamide/timolol fixed combination (n ¼ 6) than the latanoprost/ timolol fixed combination (n ¼ 0) (P ¼ 0.040), while the latanoprost/timolol fixed combination demonstrated more conjunctival hyperaemia (n ¼ 9) than the dorzolamide/timolol fixed combination (n ¼ 2) (P ¼ 0.045). One patient was discontinued early from the dorzolamide/ timolol fixed combination due to elevated IOP. Conclusion This study suggests that the daytime diurnal IOP is not statistically different between the dorzolamide/timolol fixed combination and latanoprost/timolol fixed combination in primary open-angle glaucoma and ocular hypertensive patients.

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