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The paper studied the effect of microbial polysaccharides on the leukogram of laboratory animals and studied the dynamics of peripheral blood parameters with an assessment of immunobiological reactivity based on established patterns of physiological status. The results of numerous studies of the state of natural resistance of farm animals indicate that protective forces are a dynamic indicator, and is determined both by the genetic characteristics of the body and the impact of various environmental factors. This circumstance allows directionally influencing the formation and manifestation of the body’s defenses. Thus, the study of the immunological reactivity of the organism of farm animals becomes relevant for understanding the pathogenesis of diseases, for rational pathogenetic therapy. The problem of increasing the nonspecific resistance of productive animals has not lost its relevance in the current difficult economic situation in Russia. This fact is dangerous by the manifestation of enzootic outbreaks of infectious diseases and a gradual decrease in the breeding value of animals.

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The study of immunological relationships in the functional system “mother-placenta-offspring” can make a significant contribution to the solution of the issue of improving the safety of the population of newborn animals and poultry. The pathology of the antenatal development of animals has not been sufficiently studied. Antenatal pathology of animals is more often manifested in the form of congenital malformations (anomalies) of development. Congenital defects are usually called those that occur during intrauterine development. However, congenital malformations are also observed in the period of postnatal development – as a consequence of a violation of the further formation of organs in animals. There is a need to develop a method for determining the immunological reactivity of the animal body, which would allow to assess the combined functional state of cell-mediated immunological reactivity of innate and acquired immunity in the functional system “mother-placenta-offspring” and determine the factors that cause immunosuppression. Determination of the immunological reactivity of the animal body includes a blood test by conducting a biological test, which uses the biological activity of red blood cells in the Nitroblue Tetrazolium Test and according to their sorption activity-more than 40% - animals are classified as individuals with reduced immunological reactivity among similar ones.