336 children with lymphoproliferative syndrome were examined to determine and develop criteria for predicting the risk of developing the primary form of Epstein-Barr viral infection, recurrent respiratory diseases, adenovirus infection. On the basis of the obtained results, criteria were developed for predicting individual risk of developing diseases with lymphoproliferative syndrome, the main parameters of which were significant risk factors revealed during the study. The method of prediction of risk and early diagnostics of diseases with lymphoproliferative syndrome convenient in use to pediatricians, infectologists and specialists of medical institutions, which allows to isolate children with high risk of developing lymphoproliferative syndrome and to diagnose in a timely manner the primary form of Epstein-Barr viral infection, recurrent respiratory diseases, adenovirus infection tonsillary form.

Currently, the issues of diagnosis of hypoxic-ischemic encephalopathy (cerebral ischemia) in premature newborns are relevant all over the world. The frequency of occurrence of hypoxic-ischemic encephalopathy is from 2 to 9 cases per 1000 newborns, there are negative consequences: 10–15% – fatal, 25–30% disability. The purpose of the study is to determine the clinical and neurological features of cerebral ischemia of varying severity in premature newborns using the Sarnat scale. As a result of the survey of premature newborns with cerebral ischemia, new data on the clinical and neurological status of premature children were obtained on the Sarnat classification, which can be widely used for further diagnostics and when choosing therapeutic tactics.

A ventricular septal defect is the most common congenital heart disease. With the improvement of cardiac surgery, the survival rates of children with heart disease have improved. In addition to clinical and hemodynamic improvement, an important task is to study the perception of the quality of life of children with an interventricular septal defect. The purpose of the study is to compare the quality of life of children with a ventricular septal defect. Materials and methods of the study: a survey was conducted of children with ventricular septal defect 3-17 years old (median age 9 years (Q1-Q3 - 5-12 years), as well as their parents using the Russian-language version of the international tool Pediatric Quality of Life Inventory (PEDsQL) 3.0 Cardiac Module used to assess the quality of life of children with diseases of the cardiovascular system. Results: the quality of life on the “heart problems” scale in children operated on for an interventricular septal defect was significantly lower than in children without surgical defect correction. In patients with FC | and || (n = 14) according to NYHA and Ross, the quality of life was statistically significantly lower on the scales “heart problems”, “anxiety associated with treatment”, “learning problems” than in patients with FC 0 (p <0.05). The quality of life of children with a body mass index below the norm on the “heart problems” scale was significantly lower than in children with a body mass index higher and within the norm (p <0.05). Conclusions: the quality of life of children with a ventricular septal defect may be impaired. Nevertheless, children without operational correction, with normal and above normal levels of physical development, in the absence of heart failure, better perceive the quality of life. In order to provide high-quality care, in addition to a thorough clinical assessment, quality of life should be an important aspect of the comprehensive treatment of heart disease

The aim of the study was to assess heart rate variability in children with a ventricular septal defect (VSD). Material and methods: Holter monitoring was performed in patients with ventricular septal defect from 3 to 18 years of age with an assessment of the temporal and spectral parameters of heart rate variability. Conclusion: in children with VSD, a decrease in the parameters of the temporal analysis of heart rate variability compared with healthy peers (p <0.05) was observed, more pronounced in patients with operative correction of the defect, as well as an increase in the low-frequency spectrum power (LF) as an indicator of amplification sympathetic effects on heart rate. A statistically significant correlation was found between the SDNN, SDANNi parameters and the pressure levels in the right ventricle and pulmonary artery (ρ = 0.5, p <0.01) in the group of patients with benign VSD without operative correction of the defect. The decrease in indicators of the temporal parameters of heart rate variability was inversely correlated with an increase in the postoperative period. Conclusions: in children who underwent surgical closure of the VSD, there was a disturbed heart rate variability, which had an inverse correlation with the duration of the postoperative period

To date, the question of the effect of the nature of the course of bronchial asthma on the state of bone tissue in patients is being studied. 465 children with bronchial asthma aged 7 to 16 years were monitored. The examined performed ultrasound osteodensitometry. We found that 72.3% of patients with bronchial asthma had a low body mass index, and in 22.1% of the examined body mass index exceeded the average values. Only in 5.6% of patients its value was within the normal range. The average level of physical development was revealed in 64.3% of patients, above the average - in 16.5%, below the average - in 12.9%, and high and low physical development in 4.1% and 2.2% of patients, respectively. According to ultrasonic osteodensitometry in the presence of asthma in patients, a significant decrease in the mean values of the bone density index, broadband ultrasound attenuation and ultrasound propagation velocity relative to the comparison group values was registered. In patients receiving long-term inhaled glucocorticosteroids, all densitometry indicators were lower than in patients who did not take them or who were on short courses of this therapy. When analyzing the gender characteristics of ultrasound osteodensitometry, we identified the fact of a greater risk of developing bone fractures in female patients.