Background: Malignancy is one of the principle causes of death both in developed and developing countries.Methods: 102 lung, GIT and Breast malignancies patients were selected. The various hematological abnormalities in lung, GIT and breast malignancies were evaluated by estimation of hematological parameter. Complete hematological investigation was performed using Abbott cell-3700dyn hematology analyzer and peripheral smear using Field's stain.Result: Hematological abnormalities were seen in Lung, GIT and Breast malignancies. The Anemia in 71(69.6%) cases of malignancies is most common hematological manifestation. The predominant peripheral smear finding was that of normocytic normochromic anemia (57.7%). The prevalence of leucocytosis and thrombocytosis were 33.3% and 36.2%. Conclusion:The present study showed a definite association of hematological manifestations viz anemia, leucocytosis and thrombocytosis with lung, GIT and breast malignancies.

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