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Recebido em 27/11/12; aceito em 24/6/13; publicado na web em 2/8/13The influence of the composition and preparation method on the sol-gel transition temperature (T sol-gel ) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of T sol-gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407 ® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the T sol-gel values. In contrast, the addition of microparticles caused a reduction in T sol-gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.

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