No abstract

One of the critical factors with a broad impact on health is obesity. Besides its cardiovascular comorbidities, obesity’s probable association with hypogonadotropic hypogonadism inmen will be discussed in this article by reporting a severely obese boy, presenting with the absence of secondary sexual characteristics and hypertension. The hypothalamus-pituitary-gonadal axis can be influenced by several mechanisms at different levels of the axis. Some of these pathophysiological mechanisms, related to our case are explained to explore the association of obesity with reproductive disorders. Adipose tissue plays a prominent role in the metabolism of hormones that are secreted by other glands. Obesity as a preventable risk factor is valuable to be researched, to decrease the burden of its morbidity and mortality. Thus more studies should be done in the future to determine the complex network of factors contributing to hormonal imbalances seen in obese people.

One of the most significant factors with a broad impact on health is obesity. Besides cardiovascular comorbidities caused by obesity, its probable association with hypogonadotropic hypogonadism in men was discussed in this article. We described a severe obese boy, presenting with no secondary sexual characteristics and hypertension. The hypothalamus-hypophyseal-gonadal axis can be influenced by multiple mechanisms at different levels of the axis. Some of these pathophysiological mechanisms, related to our case, were explained aiming at explaining the association between obesity and accompanied reproductive disorders. Adipose tissue, as an essential influencer, insignificantly affects the metabolism of hormones secreted by other glands. Obesity, as a preventable risk factor, is valuable to be researched to decrease the burden of its induced morbidity and mortality. Thus, further studies should be conducted to exactly determine the complex network of characteristics impacting hormonal imbalances in obese individuals.