An 18-year-old female with neurofibromatosis presented for enucleation biopsy of a slow-growing soft tissue masson her right anteromedial arm during the COVID-19 pandemic. Ultrasonography was used in the mapping of thebrachial plexus and the identification of possible neurofibroma along peripheral nerves. An interscalene brachialplexus nerve block was successfully and safely achieved with ultrasonographic and peripheral nerve stimulatorguidance. Ultrasound-guided and nerve stimulator-guided peripheral nerve blocks are safe and viable anestheticmanagement options for patients with neurofibromatosis, especially in this time of the COVID-19 global pandemic.