The purpose of this study was to study the immunomodulatory and clinical properties of the Georgian drug “LAZOLEX” in patients with Recurrent Aphthous Stomatitis (RAS). Clinical and Immunological parameters were studied in 50 patients, the results showed the correlation between the condition of immune system and the severity of the RAS, i.e., the most severe immunosuppression was recorded in patients with severe stomatitis. 5% Gel of “LAZOLEX” compared to traditional therapy, showed the same high clinical activity, but the presence of immunocorrective properties in LAZOLEX manifested itself in an improvement in the quality of patient treatment: decrease of time of epithelization and a significant increase in the duration of remission. Conducted clinical, laboratory and immunological studies allow us to recommend LAZOLEX for active use in dental practice for RAS.

The aim of our research was to study efficiency of applying the new national gel Lazolex (5%) during the treatment of chronic recurrent apthous stomatitis. To achieve this aim we examined and treated 19-55 years old 54 patients. The patients were devided into two groups. Each group included 27-27 patients. We used the same treatment in both groups, but in the first group during the local treatment we applied the gel Lazolex and in the second group we used the ointment zovirax(5%). Studies of our examination showed that the 19 patients (70,37±0,42%) from the first group 27(50±50) had important improvement, 6 patients (22,22±1,87%) had improvement. there was no efficiency in 2 patients (7,41±1,87%) with grave forms of chronic recurrent apthous stomatitis. In the second group after applying Zovirax only five patients from 27 (50±0,5%) had important improvement with the easy forms of chronic recurrent apthous stomatitis (18,52±0,9%) improvement was shown with 15 patients (55,6±0,8%). 7 patients (26,16±1,67%) from which 2 had grave forms and 5 had medium forms of disease had no efficiency. It is concluded that applying of national gel Lazolex (5%) accelerates the epithelisation on lips and skin and growth the remission process of disease. It does not have side effects . Thus, it is recommended to apply Lazolex during the treatment of chronic recurrent apthous stomatitis.

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