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The synthesis of a cyclic heptapeptide, delavayin-C, cyclo(gly-tyr-tyr-tyr-pro-val-pro) is described. The structure of this compound was established on the basis of analytical IR, 1H NMR and FAB mass spectral data. The antibacterial and antifungal activities of this peptide are also described.

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The present study describes designing, synthesis and anticancer screening of a proline rich cyclic octapeptide polycarponin C, by solution phase synthesis. The synthesis was carried out by coupling a tetrapeptide Boc-Pro-Thr-Leu-Pro-OH with another tetrapeptide Boc-Pro-Val-Leu-Phe-OH, followed by cyclization of the linear octapeptide.The structure of the synthesized compound was then confirmed by spectral analysis. From the results of biological activity, it was concluded that the compound has shown moderate activity against SR human tumor cell lines of Leukemia when compared with Vincristine as a standard.

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