Objectives: To clinically evaluate and compare changes in periodontal parameters and superoxide dismutase activity after non-surgical periodontal therapy with and without micronutrient supplementation in postmenopausal women with periodontitis. 60 postmenopausal women with periodontitis were divided into group I and Material And Method: group II. Group I patients was given systemic micronutrient supplementation along with scaling and root planing. Group II patients were treated with scaling and root planing only. Serum and saliva samples were collected and evaluated for SOD level at baseline and 3 months along with clinical parameters. Salivary and serum SOD values sig Result: nificantly improved with periodontal treatment. Improvement in systemic enzymatic antioxidant status along with reduction in gingival inflammation and bleeding on probing (%) sites was significantly greater in group I as compared to group II. Conclusions: Adjunctive micronutrient supplements reduce periodontal inflammation and improve the status of systemic enzymatic antioxidants in postmenopausal women