In this paper we observe the association between changes in air quality and number of hospital admission during "holi-the festival of colours". Proposed research performed during holi festival, where playing colour are very common practice. Fine particle and its ion concentration were analyzed by air monitoring and ion chromatography. Reported concentration profile of fine particle were 25-40 μg m −3 , 54-171 μg m −3 , and 35-70 μg m −3 , for PM 2.5 and while for PM 10 , 53-251 μg m −3 , 92-291 μg m −3 , and 58-277 μg m −3 , respectively, which are more than the permissible limit. The major anions (Sulphate, Nitrate, and Chloride) and cations (Sodium, Potassium, and Magnesium) were obtained on fine particle with higher permissible limit. PM 2.5 were 67 μg m −3 , which was 1.11 times and ~ 2 times higher than Indian and WHO standards, moreover, probably first time reported during holi festival. Very limited study is available on association between fine particle (PM 2.5) available in air quality and number of hospital admission. The pollution generated due to holi festival and hospital admission related data were collected in four different locations and nine hospitals near by the selected study area, respectively. Empirical relationships have been developed between particle concentration due to colour festival and hospital admission.