Primary liposarcoma in the pyriform sinus of the hypopharynx is extremely rare and shows a distinct male preponderance. The complete resection has been a choice of the treatment, however the rate of recurrence is relatively high. This report presents a pregnant case with well-differentiated liposarcoma of the hypopharynx. The recurrent tumor involving the pyriform sinus and aryepiglottic folds was removed by an intraoral approach using direct suspension microlaryngoscopy and a Holmium-YAG laser. The tumor size was 30 mm x 15 mm x 10 mm. An additional systemic examination showed no distant metastasis. The patient delivered a healthy female baby without any trouble. The well-differentiated type of liposarcoma frequently shows local recurrence; however it rarely shows lymph node or distant metastasis. A complete function preserving excision such as intraoral approach may therefore appear to be an adequate management plan, however careful follow-up of these patients at regular intervals is also imperative for detecting of recurrence.
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