IVIG and HLH-2004 protocol may be equally effective in the management of HLH. IVIG may be a preferable initial regimen, to avoid the risk of secondary malignancy associated with etoposide.

Infections particularly Mycoplasma pneumoniae and HSV have been reported to be the commonest precipitating cause for Stevens Johnson syndrome (SJS) in children in developed countries and drugs are the commonest triggers reported in the Indian context. Intravenous immunoglobulin (IvIg) is emerging as a therapeutic option instead of glucocorticoids. The authors report a case of Stevens Johnson syndrome in association with Mycoplasma pneumoniae in a 5-y- old girl who recovered with IvIg therapy.

Transport of critically ill children by a specialized transport team is associated with fewer transport-related adverse events.

Toxoplasmosis should be considered in the differential diagnosis of focal brain lesions irrespective of immune status.