Background: Hemodialysis is required to the specific nurses' knowledges and the virtuous nursing care with the high standard practice for the management of end stage kidney disease patient. Nurse's knowledge about hemodialysis takes a key role in the success of this practice. This study aimed to assessing the nurse's knowledge about hemodialysis procedure and complication in Sulaimani City. Methods: A descriptive cross-sectional study was conducted in Shar Teaching Hospital from June 1, 2022 to February 2, 2022. A total 102 nurses were recruited to this study by using a convenience sample size. Data were collected by using the structured questionnaire that was about sociodemographic variables and nursing awareness about hemodialysis. Results: The study found the participant nurses were mostly female (52%), married (62.7%), in the age group (28<38 years) (78.4%), the professional diploma level of education (69.6%), and 5 -10 years of experiences (79.4%). Age group (28<38 years) and Bachler education level had a significant relationship with knowledge about hemodialysis procedure (p. value= 0.04) and its complications (p. value= 0.02. Knowledge about washing hand (33.3%), putting gloves (41.2), and chest pain and shortness of breath complication (50%) were less considerably among the nurses. Conclusions: This study has found level of knowledge about hemodialysis were considered low among nurses. Age and level of education were significantly but inconsistently associated with the knowledge about hemodialysis. Nurses did not have proficient knowledge about infection control and the complications of hemodialysis. This study recommends the continuous training to low educated nurse.