Unani system of medicine has a long therapeutic history for treatment of a variety of diseases. This system comprises of various plant, animal and mineral origin drugs. Tukhme Khurfa, seeds of Portulaca oleraceae Linn. is an important herbal drugs which have hypoglycemic activity, musakkin (sedative), munauwwim (hypnotic), mudirr-i-bawl (diuretic), antioxidant activity, hepatoprotective activity, anticonvulsant activity, anti-inflammatory activity; is recommended for the various disease like Dhayabitus (diabetes), hummiyate harra, sudae harra (headache), shiddate atash (excessive thirst), surfa harra (acute cough), sozish-i-mi'da (inflamation of stomach), sozish-i-jigar (inflammation of liver), sozish-i-bole (urinary tract infection), sarsam (meningitis) etc. The present article reviews the various classical information, chemicals and reported pharmacological activities of the drug and concluded that it is very promising drugs in respect to its traditional claim proven after contemporary research.

Punica granatum Linn is a holy fruit belongs to Punicaceae family and its uses are mentioned in various ancient texts and religious books. (It was lauded within the Old Testament of the Bible, Qur’aan, the Judaic Torah, and also the Babylonian Talmud as a sacred fruit conferring powers of fertility, abundance, and sensible luck). Pomegranate is used in various systems of medicine. The biological properties of extracts (hypoglycaemic activity, immunomodulatory activity, analgesic activity, anticancer activity,etc.) obtained from many components of pomegranate is according within the gift work. Attributed to such properties, the extracts are used in medical specialty, like within the hindrance of infection, inflammation, cholera, impotence among different applications. Phytochemical screening of the Punica granatum exposed that it contain anthocynin, flavonoides, alkaloids, tannins, triterpenes and phytosterols. This text in short reviews the ethanobotanical properties furthermore as HEALTHFUL uses with plant description. This is a trial to compile and document data on totally different side and its potential use. A lot of studies are required before the pharmacologic properties of Punica granatum can be utilised in medical care.