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Aim: This study was conducted to evaluate the serum levels of some trace-elements (zinc, copper and selenium) and antioxidant vitamins (vitamin A, C and E) in prostate cancer patients. Method: A total of 50 prostate cancer patients aged 50-70 years with PSA > 4.0 ng/dl were recruited for the study while 50 apparently healthy individual were used as control subjects. Zinc, copper and selenium were determined using atomic absorption spectrophotometer while vitamin A, C and E were determined using high performance liquid chromatography. Result: The result showed that the mean levels of Se (0.77±0.26), Zn(147.75±42.05) were significantly lower (p <0.05) when compared with the control (1.47±0.13) and (168.78±59.80) respectively. The serum copper level (187. 76±66.05) was significantly higher (p<0.05) when compared with control (126.40±31.24).The antioxidant vitamin A (0.42±0.19), vitamin C (3.62±1.81) and vitamin E (0.39±0.13) were Significantly lower p(<0.05) when compared with the control (0.68±0.32)(12.16±4.07) and (1.40±0.16) respectively. Concusion: The decreased trace elements and antioxidant vitamins may be associated with high free radicals generated due to oxidative stress in prostate cancer patient.

Azadirachta indica, reported to be antioxidative, is hepatoprotective. This study evaluates the effect of A. indica leaf aqueous extract on antioxidant enzymes (glutathione peroxidase (GPx), superoxide dismutase (SOD) in paracetamol induced hepatotoxicity in Wister rats. Twenty four rats, in four groups, each containing six rats were used. Group A was given normal saline, group B paracetamol (800 mg/kg body weight) and groups C and D paracetamol and graded doses of the extract (400 mg and 800 mg/kg body weight respectively). The animals were weighed before and after experiment. Plasma liver enzymes (alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatases (ALP), plasma and liver homogenate malondialdehyde (MDA), GPx and SOD were estimated. Results showed significant weight increase (P<0.05) in A and D and weight loss in B. ALT, AST and ALP were significantly increased in B compared with A while C and D were decreased compared wth B. Plasma and homogenate MDA were increased while GPx and SOD were decreased in B compared wth A. Groups C and D MDA were decreased with increased GPx and SOD compared wth B. The extract could be a potent antidote to paracetamol induced hepatotoxicity as indicated by the increased GPx and SOD in C and D.

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