This report provides the first evidence that expression levels of p120 in tumor tissues can be used as an independent and powerful prognostic marker for resected lung adenocarcinoma.

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The DNA synthetic activities of mannans isolated from two Saccharomyces cerevisiae strains were examined in vitro using spleen cells obtained from normal or nude BALB/c strain mice. A highly branched mannan isolated from the S. cerevisiae wild type strain induced a greater increase in mitogenic activity than those displayed by the mannan of the S. cerevisiae X2l80-IA-5 mutant strain which possessed fewer branching moieties. Acid-hydrolyzed wild type strain mannan with two-thirds of the molecular weight of the parent intact mannan showed weak mitogenicity.Increases in the DNA synthetic activities of nude and normal spleen cells were almost the same as that of wild type strain mannan, while nylon wool column-passed spleen cells obtained from both normal and nude mice did not show mitogenicity with this mannan. The results indicated that the mitogenic activity was responsible for the highly branched structure of the wild type strain mannan, and that this mannan is a B-cell mitogen.It has been shown that several bacterial constituents such as lipopolysaccharides (10), purified protein derivative (28), polymerized ftagerin (5), and dextran sulfate (25), are mitogenic against B cells. There is disagreement, however, in the previous findings concerning the mitogenic potency of dextran, a non-anionic polysaccharide. A few papers reported that dextran had no effect on DNA synthesis (2, 8), but another paper showed that dextrans displayed mitogenic activity (6, 20).We have recently reported that two mannans isolated from Saccharomyces cerevisiae wild type strain (commercially available bakers' yeast) and X2180-lA-5 mutant strain had strong antitumor activities against solid forms of sarcoma 180 and Ehrlich carcinoma (18), and also demonstrated that these mannans were not contaminated with bacterial lipopolysaccharides (19). Results obtained in the preceding study which indicated that the intensity of antitumor activity evoked by the mutant strain mannan (abbreviated as A-mannan) containing very small 913

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