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SYNOPSIS A patient with hemiplegic migraine who was treated successfully with flunarizine is presented. A fifteen‐year‐old boy developed right hemiparesis during several migraine attacks. Regional cerebral blood flow (CBF) measurement using intravenously injected xenon 133 showed that the CBF was about 10‐15% lower in left fronto‐temporo‐parietal regions than that on the contra‐lateral side. After the treatment with flunarizine at a dose of 10 mg/day, he has been free of migraine attacks and hemiparesis disappeared. Regional CBF 1 month after treatment showed no decrease in any region of the brain. The findings indicate that flunarizine reversed the neurological deficits by increasing CBF by its vasodilating action.

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