GROalpha and IL-8 are necessary for the growth of lung, stomach and colon adenocarcinomas, and can be inhibited by the hexapeptide, antileukinate. The findings suggest the possibility of using alpha-chemokine receptor inhibitors in the treatment of adenocarcinoma.
Melanoma growth stimulatory activity (MGSA/GRO ␣ ) is a 73 amino acid peptide sharing sequence characteristics with the ␣ -chemokine superfamily. MGSA/GRO ␣ is produced by diverse melanoma cell lines and reported to act as an autocrine growth factor for the cells. We tested the binding of MGSA/GRO ␣ to melanoma cell lines, Hs 294T and RPMI-7951, and found that these cells could bind to MGSA/GRO ␣ but not to interleukin-8.Recently ,
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