A series of synthetic transformations were successfully and
safely scaled up to multigram quantities using focused microwave irradiation with a continuous flow reaction cell that was
developed in-house and which can be easily adapted to commercially available instrumentation. The representative reactions that were investigated included aromatic nucleophilic
substitution (SNAr), esterification, and the Suzuki cross-coupling
reaction. In general, the product yields were equivalent to or
greater than those run under conventional thermal heating
conditions.
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