Granuloma Umbilical from major problem in neonates and young infants. It is reported frequently by mothers as continuous leakage of secretion at umbilicus site following cord separation. Delayed management of granuloma, it remain oozing and causes persistent irritation for long period reach weeks. Several management modalities were performed for umbilical granuloma including; using cook salt, ligation of the granuloma, cauterization chemically with silver nitrate or copper sulphate, electro-cauterization, cryocauterization and excision surgical . Aim of the study: Evaluate mother knowledge and performance regarding using of cook salt for management of infants with granuloma umbilical. Subject and Methods: Research Design: A quasi-experimental research design was used Setting: The study was conducted at outpatient pediatric department of Tanta and Menoufia University Hospital. Tools: Two tools were used: Structure interview schedule was developed by the researcher included three parts: Tool I: Biosocial data of infants and their mother, mothers' knowledge and reported practice was evaluated by using observational check list about cook salt use for umbilical granuloma. Tool II: Guideline reported educational intervention for the mothers Results: Infants with granuloma showed complete resolution after course of cook salt treatment. Conclusion: Using of cook salt for management umbilical granuloma is costeffective, simple curative and safe mode of treatment which can be performed by mothers at home. Recommendation: Using of cook salt as a treatment modality should be more encouraged by the health staff.