Aim: Observe the measurements of the intercanine and intermolar space of digital models and compare the reliability of different software, Meshmixer, 3D Slicer and Nemocast. Methods: Inclusion and exclusion criteria were used to obtain the study sample. Thus, a sample made up of 29 patients obtained from a database with their respective digital models was obtained. Results: In the results of the measurement in the three programs we obtained that the difference in the upper intercanine space is 1.43 mm, in the lower intercanine space it is 0.26 mm, in the upper intermolar space it is 0.11 mm and the lower intermolar space is 0.25mm. Conclusion: There was no significant difference between the results obtained in the three Meshmixer, Nemocast and 3D Slicer programs, thus providing reliable and safe data for diagnostic and planning studies in orthodontics.