Marine actinobacteria have emerged as a well-known potential source of secondary metabolites which possess useful properties in many fields including medical and agricultural applications. The aim of this research was investigated the antimicrobial compounds of marine Streptomyces celluloflavus isolated from mangrove soil samples taken in Can Gio mangrove soil (Can Gio district), Ho Chi Minh City, Vietnam. Herein agar-well diffusion method was employed to measure antimicrobial activity of the culturing medium extract against four pathogenic bacteria strains. The compound harvested were then analysed by GC-MS method. Thirty-one bioactive secondary metabolism compounds were identified in the ethyl-acetate – hexane extract of Streptomyces celluloflavus. The identification of these bioactive secondary metabolites compounds is based on the peak area, retention time, molecular weight, molecular formula, and antimicrobial actions. GC-MS analysis result revealed the presence of the 7 major components including 2-pentanone, 4-hydroxy-4-methyl, Cycloheptasiloxane, tetradecamethyl, Cyclododecane, 1,1,1,3,5,7,7,7-Octamethyl-3,5-bis(trimethylsiloxy)tetrasiloxane, Benzoic acid, 2-hydroxy-, 1-methylethyl ester, 1-Hexadecene and Heptasiloxane, hexadecamethyl . Therefore, it could be deduced that the remedial potential of mangrove soil Streptomyces celluloflavus based on plentiful compounds existing in the extract was highly expected.
