This study was planned to investigate the probable protective role of Salvia officinalis have in the nanoparticles and aqueous extracts on female rats which exposed to Bisphenol A. At the end of the experiment the blood samples were collected by heart puncture to evaluate the RBC and WBC count, Hemoglobin, Platelets as well as follicle stimulating hormone (FSH), luteinizing hormones (LH), estrogen, creatinin, urea, aspartate aminotransferase, alanine amino transferees and alkaline phosphatase were estimated furthermore after the rats were scarified Liver, Kidney, Uterus and ovary were collected for histological study. The result shows significant decrease in the RBC, PLT and Hb count in the BPA group in comparison with the control and SOSNPs and SOE groups. In addition, there is a significant increase in WBC count and estrogen level in the BPA treated rats in comparison with control, SOSNP and SOE treated rats. As well as, there is significant increase in the liver enzymes (AST, ALP and ALP) in the BPA treated rats in comparison with control and SOSNP & BPA treated groups. Histological studies show presence of vacuolation with absence of radial arrangement in the hepatocytes in the liver of rats. The histological studies for the uterus of rats Beside ovarian sections BPA reveled mature follicle without oocyte with cyst like structure in the ovary in comparison with control group, these effects were relieved by the role of SOSNP and SOE in alleviating the effects of BPA on studied parameters.