Benign prostatic hyperplasia (BPH) is a considerable public health problem prevalent among older men. Despite its eminent prevalence, the etiology of BPH is not well understood. Accumulating evidence indicates that modifiable risk factors of cardiovascular disease may also increase the risk of BPH and potentially contribute to BPH development. This study evaluated the ameliorative effect of Ceiba pentandra leaf on some lipids profile indices and bilirubin concentration of rats induced BPH. Thirty six Wistar rats were divided randomly into six groups (n = 6). All the experimental groups except the normal control were induced benign prostatic hyperplasia using testosterone propionate and estradiol valerate at a dose of 400 µg and 80 µg respectively, for 21 days. After induction, rats in the negative control (BPH Control) group received no treatment. Rats in the standard control group received finasterides (1mg/kg body weight), while rats in the low dose extract, medium dose extract and high dose extract groups received the plant extract according to their body weights in kilogram at 500 mg/kg, 1000 mg/kg, and 1500 mg/kg respectively. Normal Control group received only feed without any special treatment. The animals in all the groups were allowed access to water and feed ad libitum for 28 days. The rats were anaesthetized after treatment period. Blood samples were collected and serum harvested for analyses using standard methods. Result showed that Ceiba pentandra leaf had ameliorative effect on the lipids profile analyzed.