Sclerodermiform syndrome is Common in diabetic, it encompasses a set of manifestations that preferentially affect the hands and back, but the association of type 1 diabetes with systemic sclerosis is a rare entity. We report the case of 18-year-old patient from a consanguineous marriage, with a history of acute myeloid leukemia which he was treated by an allograft in France associated with chemotherapy 9 session and immunosuppressants currently in complete remission, diabetic type 1 for 4 years, hypothyroidism under levothyrox 50ug / d. At the interrogation the patient reported the consequences of the graft were marked by stage I cutaneous GVHD confirmed by skin biopsy of which he received corticosteroid therapy at a dose of 10mg / day in addition to neoral or slightly atrophic hyperpigmented macules not sclerotic at the level of the back and the lateral surface of the left foot. The patient also had corticosteroid-induced complications, including diabetes and osteoporosis. On physical examination tendon retraction, elbows and finger, Amyotrophy of the hands, palpable thyroid not increased volume allowed for glycemic imbalance. At TSH biology = 6uui / ml, HBA1C = 8%, anti-GAD antibody negative to cervical ultrasound: thyroid hypotrophy with thyroid nodules classified EUTIRADS 2. The patient is referred for follow-up in dermatology. The association of sweet diabetes and sclerodermiform lesions is frequently linked to the glycemic imbalance responsible for an accumulation of extracellar matrix and excessive glycation of collagen. The search for signs of scleroderma should be evoked in front of a diabetic hand syndrome to Watch for and treat associated pathologies.

Thalassemia is a condition that affects hemoglobin synthesis and is one of the most Common hereditary illnesses in the world. Patients with thalassemia major require several blood transfusions. Multiple blood transfusions cause thyroid dysfunction, which leads to iron excess. We report the case of 35-year-old, followed in hematology for deep iron deficiency anemia who has benefited from a transfusion repeatedly diagnosed with beta thalassemia. At the interrogation, the patient reports a moderate gain of weight not quantified, hair loss and sensations of chills, chronic constipation, without other associated signs including no other signs of hypersecretion or anterior pituitary hyposecretion, no tumor SD. The physical examination finds a conscious patient, Normocardium, normal build, dysmorphic SD, palpable thyroid not increased in size. Microcytic hypochromic anemia, TSH at 10 mIU/l (0.35 -5.1) mIU / l, T4 at 10.6 pmol / l (10.6-19.4) pmol / l T3 to 2.88 pmol / l (3.8-8.4) pmol / l. Objective cervical ultrasound thyroid gland increased in size at the expense of the thyroid lobe with thyroid nodules classified EU-TIRADS 2 and 3. The patient was put on levothyrox 75ug/d. Thyroid disorders are common in β-thalassemia patients who have been transfused multiple times.

Stroke disease can result from traditional cardiovascular risk factors and by cancer, especially adrenocortical corticosteroids by hypercoagulability and megaloblastic anemia would be possibly though hyperhomocysteinemia. We report the case of a patient aged 65 years, without significant pathological , diagnosed with a left adrenocortical retained in front of a mass at the level of the left adrenal compartment, irregular shape, fairly well limited, isodense to spontaneous contrast (33UH), enhanced by the PDC in a heterogeneous way delimiting areas of necrosis measuring 9cm, with an absolute Wash out of 25% and relative to 11%. Associated with an attack of the general condition evolving rapidly gradually is a weight loss of 16 kilogram over 2 months. With the biological Assessment a cortisol cycle broken with cortisolemia from midnight to 12, braking at 1.7 and CLU at 4 times normal. The patient presented during hospitalization megaloblastic anemia and thrombocytopenia with vitamin B12 deficiency confirmed by myelogram and anti-intrinsic positive antibody treated with courses of hydroxocobalamin in intramuscular, after 4 days the patient presented upon waking left hemiplegia, left facial paralysis with dysarthria on Cerebral CT scan showed ischemic stroke of the right middle cerebral artery. The patient was put on anticoagulant therapy. The evolution was marked in a context of improvement of anemia and thrombocytopenia and the resumption of motor skills of the left hemibody. The patient is put out before the criterion of non-operability to predict a tumor excision after a good medical preparation for surgery. There is a relationship between Biermer anemia and neoplastic pathologies in stroke disease.