This study revealed that bromelain  from  pineapple and quercetin from fenugreek mixture were active in reducing the effect of arthritis the body diameter measurements  within day 4 until the day 10 of peak of induction of arthritis  reached the maximum  at 5.8 for CRP (mm/hr) ESR (mg/Dl) and reduced it  to nearly  the normal value 4.3 for CRP and  1.9 for ESR at day 30  with concentration  350 mg/kg of (bro, quer) and within day 4 until the day 10 of peak of induction of arthritis  reached the maximum  at 2.8 mm of paw volume and reduced it  to nearly  the normal value 2.9 for  300 mg/kg  of (bro, quer) and  2.6 for 350 mg/kg (bro, quer) at  day 30  with concentration  350 mg/kg , While within day 0 until the day 10 of peak of induction of arthritis  reached the maximum  at  83 ng/dl for  IgG2 and  70 ng/dl for  IgG1  and  40 IgG reduced it  to nearly  the normal value  68 ng/dl  of IgG2 for  350 mg/kg  of (bro, quer) and  57ng/dl of IgG1  and 39 ng/dl of IgG for 350 mg/kg (bro, quer) at  day 30  with concentration  350 mg/kg  .Also within day 0 until the day 10 of peak of induction of arthritis  reached  the lowest body weight  at 18 mg of paw volume and increasing it  to nearly  the normal weight 19mg for  300 mg/kg  of (bro,quer) and  21 mg for 350 mg/kg (bro, quer) at  day 30  with concentration.

A mixture of date palm pollen (dried or ethanol- extracted) and vitamin D3 IN 4000 IU and(dried or ethanol- extracted ) Eruca sativa were used to treat 20 albino mice to determine the activity of the testosterone hormones. The mice divided into five groups each group contains 5 of mice male groups( treated with ethanol extract of the mixture at 400, treated with ethanol extract of the mix at 500, treated with dried extract of the mixture at 400, and treated with dried extract of the mixture at 500) mg \kg respectively, significant differences in the results in the highest effect of 500mg/kg dried powder of the mixture of date palm pollen and vitamin d3 and Eruca sativa on group 4 at day week 6 compared to the control in group 5. The lower effect, according to the significant differences in group 1 at week three yet it’s still promising due to a higher level than control which is the control. Other were with treatment with gradual change for the extreme results in week six the testosterone level was measured gradually