Kanakasavam is a polyherbal formulation with 14 ingredients used mainly in Swasa roga (respiratory diseases). In clinical practice, Kanakasavam is primarily used to treat respiratory diseases. It contains purified datura, which acts as a bronchodilator and has anti-inflammatory properties. It is also known to provide relief from an acute asthma attack and increases the airflow to the lungs by dilating and relaxing the bronchial passageways. Kanakasavam is also used for bronchitis, productive cough, chronic fever, haemorrhages, and lung injury. In addition, it is also beneficial in the treatment of the common cold, rhinitis and abnormal nasal discharges. This article is an attempt to analyse the formulation critically.

Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia resulting from defects in insulin secretion, insulin action or both. The disease is classified based on physiological status, mainly categorised into type 1 and type 2. Recent studies show that type 2 diabetes mellitus is being considered as being caused due to the impairment in the immune system, which has already been explored as one of the reasons causing diabetes or prameha in Ayurveda. The patients of prameha inherently carry the risk of impaired agni and depleted ojas status, that is, hypometabolic and immuno-compromised state. The primary goal is not merely to achieve normoglycemia but also to minimise its complications. In this context, many Ayurvedic drugs are undergoing extensive research. The chronic complications of diabetes are broadly divided into microvascular and macrovascular, with the former having a much higher prevalence than the latter. Microvascular complications include neuropathy, nephropathy, and retinopathy, while macrovascular complications include cardiovascular disease, stroke, and peripheral artery disease (PAD). This choornam is presumed to act as an agent to clear occlusions in the microvascular and macrovascular vessels, and this article intends to delve deeper into the mode of action of Guggulupanchapala choornam in breaking the samprapathi of prameha and its associated comorbidities. This article is an attempt to shed some light on the application of Guggulupanchapala choornam in the treatment of prameha and thereby reducing the various complications which follow it.

The discs which are located in between the vertebras to act as shock absorbers during jolts to prevent spine injuries get either dislocated, bulged out or get thinned on continuous pressure being exerted upon them either by travel or a posture that is unsuitable to their alignment. In cases of discs getting thinned out and the height of these discs get reduced due to various causes produce undue pressure over the cervical spine resulting in oxidative stress and production of free radicals in the body causing deterioration of bone tissue and bone mass leading to regulation of RANKL/OPG ratio levels causing degeneration of bone. It is possible to resurrect the dehydrated discs with rehydration using Balamula (Sida cordifolia root) with the help of its properties and actions that it can positively act upon the area by refilling the gaps of erosions and assure a recovery with the proper administration of it in the form of ghee which has been processed with it and its intake being after food. Material & Methods: Various Ayurvedic classical textbooks and published journal articles were reviewed and analysed. Results: Evidences from various studies show that the phytochemicals obtain from Balamula (Sida cordifolia root) and Go- Ghritam (cow’s ghee) acts as antioxidant, reduces the activity of osteoclast and bone resorption by inhibiting RANKL receptor pathway. It also has anti-inflammatory, anti-arthritic, anti-analgesic effect that found to be effective in reducing the symptoms of cervical spondylosis.

In Ayurveda prevalence of Vayu mahabhuta is considered as prime factor that causes deterioration of qualities of Kapha in Greeva stana hence prescription of drugs having Vatanuloma and qualities of Prithvi and Jala mahabhuta would be very effective. In the present study humble attempt is made to evaluate the effect of Balamula Ghritam internally and combined with Mashasaindhava Tailam as external pack in arresting further degeneration. Materials and methods: 40 patients fulfilling the inclusion criteria after signing the informed consent form were selected from SJSACH [IEC N0-IEC/SJSACH/ 05/2021, CTRI N0 - CTRI/2021/07/034968]. It is a single arm prospective open randomized clinical study. Patients were administered with 10ml of Balamula Ghritam morning and night after food and Mashasaindhava Tailam as pichu (external pack) over the cervical area for 21 days with two follow ups after the completion of the trial. Result: Subjective parameters were assessed using Friedman test and Wilcoxon signed rank test and objective parameters were assessed using paired sample t test. All the parameters had highly significant results with significant p value at the end of the treatment. Conclusion: The combined effect of Balamula Ghritam and Mashasaindhava Tailam was very effective in the management of cervical spondylosis. The critical analysis of the contents of Balamula Ghritam and Mashasaindhava Tailam acts as antioxidant, removes free radicals ROS, reduces the activity of osteoclast and bone resorption by inhibiting RANKL receptor pathway. It also has anti- inflammatory, anti-arthritic, anti-analgesic effect that found to be effective in reducing the symptoms of cervical spondylosis.