Background: Now a days superficial fungal infections become endemic in a hot humid region/tropic region like Bangladesh. In outpatient department of dermatology most of the patients come with dermatophytic infection. Most of them are maltreated or inadequately treated. We, dermatologist, are facing difficulties in treating these patients. Materials and Methods:In this study, we tried to find out the effective doses and duration of antifungal drugs Terbinafine and Itraconazole.Result: Total 92 patients with dermatophytosis of either sex aged 22-60years without any significant systemic diseases were included in this study. The patients were randomly divided into two groups; Group A and Group B. Group A was treated with Terbinafine 500mg daily and Group B was treated with combination of Terbinafine 250 mg & Itraconazole 200mg daily. Duration of treatment was for 6weeks.Itraconazole and Terbinafine containing combined groups showed significantly higher cure rates than terbinafine only groups both at 4 and 8 weeks (P < 0.001). Conclusion: combination of dailyTerbinafine 250mg with Itraconazole 200mg was more efficacious than Terbinafine 500mg

This is a descriptive type of longitudinal study conducted among Hundred clinically diagnosed cases of dermatophytes attending at skin out patients department of Zainul Haque Sikder Women’s Medical College, Bangladesh from August 2018 to August 2019 to observe the efficacy and safety of voriconazole among the resistant cases of dermatophytosis. Among 100 patients, 40 were males and 60 females between ages 20 and 65 years of all age group with clinical, mycological diagnosis of dermatophytosis. To find out antifungal resistance pattern as well as efficacy and Safety of Voriconazole among dermatophytes. (Skin, hair and nail samples were taken aseptically. All patients were resistant against present treatment options like: fluconazole, itraconazole & terbinafine etc.) All patients were treated with Voriconazole. Duration of treatment of each patient was 4 weeks. Resistance against fluconazole and terbinafine was most common, 85.33% and 58% respectively. 5% resistance against voriconazole was observed in this study. Resistance against fluconazole was noted among all species of dermatophytes, followed by terbinafine. Among 100 patients 80% was fully cure and rest of 15 % were partially cure with 5% resistant of Voriconazole which is seems to be more effective and safer against dermatophytosis.