Genes are basic physical and functional unit of heredity. Genes are made up of DNA. Some genes act as instructions to make molecules called proteins. However, many genes do not code for proteins. Gene Mutation refers to modification of gene’s DNA sequence. Mutation of genes can vary within a genome and between genomes. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes. Because mutation is one of the fundamental forces of evolution, this work looked into the various computer software tools that can be used for genetic mutation analysis. These applications were reviewed stating the OS platform it depends on, the nature and format of data it accept, the input and output from these software tools and urls were they can be found were also stated.

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