Objective: This study aimed to investigate the mediating role of positive and negative affect in the association of perceptions of parental involvement, autonomy support, and warmth with resilience among Adolescents with Addicted Parents. Method: In this descriptive-correlational study, 63 Adolescents of Addicted Parents studying in Zahak and Hirman, located in Sistan and Baluchestan Province in Iran, were selected using convenience sampling method. The participants completed the questionnaires on perceptions of parenting styles, resilience, and positive and negative affect. Data were analyzed via the correlation coefficient and path analysis. Results: The results showed that the adolescents’ perceived parenting styles were directly and significantly related to positive affect and resilience (P < 0.01). Moreover, the results of the path analysis indicated that mediated by positive affect, the adolescents’ perceived parenting styles predicted resilience indirectly (P < 0.01). Conclusion: Given the results of this study, perceived parenting styles can directly and indirectly predict resilience. It can be concluded that adolescents’ perceived parenting styles can enhance resilience among them through promoting positive affect.