A B S T R A C TThe ameliorative effect and antitumor activity of basic curcumin nanoparticles modified with basic nano black seeds (nigella sativa) and calcium ascorbate were evaluated. eighty female mice were divided into 4 equal groups of 20 mice each. Group 1: non -tumor bearing mice (NTBM). Group 2: tumor bearing mice(TBM). Group 3: NTBM + nanocomposite (4.750gm / kg. b.wt /day ) , orally for 6 weeks . Group 4: TBM + nanocomposite (4.750gm / kg. b.wt/day ), orally for 6 weeks . Blood samples for serum separation and liver tissues specimens were collected from all animal groups three times after 2, 4 and 6 weeks from the onset of treatment. All serum was directly used for determination of ALT and AST activities and urea and creatinine concentrations. Moreover, antioxidants enzymes (catalase, GPX, SOD), GSH and MDA were detected in liver tissue. The obtained results showed significant decrease in catalase, GPX and SOD activities and GSH concentration in liver tissue of tumor bearing mice. Meanwhile, liver MDA, serum transferases(ALT and AST) activities, urea and creatinine concentrations were significantly increased in tumor bearing mice . TBM treated with nanocomposite improve the adverse biochemical changes induced by tumor. So, this nanocomposite has potential benefits in cancer treatment.