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AT III concentrate (Behringwerke) was administered to approximate the activity up to 80-120 % on 4 congenital AT III deficient patients. AT III antigen was assayed by single radial immunodiff usion and activity was by S-2238 as heparin cofactor activity.From the determined values of antigen and activity of infused AT III, regression line of time course was obtained for each case by computor analysis using the two compartment open model.Biological half life (T 1/2) was 72. 3+35. 8 hrs for antigen and 75. 6+18. 0 hrs for activity. Distribution volume (Vd) for antigen was 7. 2+2. 43 L. Initial half disappearance time was about 24 hrs. Mean maximal increase of AT III level was 0. 27+0. 04 (mg/dl) /U/kg for antigen and 0. 82+0. 20 %/U/kg for activity.Based on the data of single dose experiments, the simulation curves of multiple administrations were calculated on the different intervals of infusion, and the reasonable steady state of concentration was considered to be achieved on the administration of 24 hr-and 12 hr-interval.One of the deficient patients was received AT III concentrate every 24 hrs for

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