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Seven pancreases from nondiabetic autopsy cases were submitted to morphometrical analysis of the islets of Langerhans as a preliminary investigation of the diabetic pancreas.The pancreatic islets were approximately simulated by spheres of different sizes randomly dispersed in the three-dimensional space; thereon the parameters of Weibull function assumed for the distribution of islet radii were estimated stereologically from chord length measurements on histologic sec tions taken from different portions of the pancreas.By means of the estimated parameters topographical comparison of the number, volume, mean radius and size distribution of islets in a unit volume was performed. The islet distribution appeared to change the pattern gradually according to the position from the pancreatic head to the tail: the head was characterized by abundance of small islets that corresponded to a slightly higher islet population thereat, whereas the tail by moderate increase of larger islets that caused a steep increase of islet volume here. To estimate parameters for the whole pancreas a histologic section from a range between the midposition of the pancreas and the one-fourth position from the splenic end was regarded to be a fairly good representative.-pancreatic islets; spherical bodies; size distribution function; parameters; topographical comparisonThe pancreatic islets are regarded as a group of spherical or ellipsoidal bodies of different sizes randomly dispersed in the three-dimensional space. In quantitation of the islets in the pancreas, as has been stressed by some authors (Lazarus and Volk 1962;Warren et al. 1966), it is impossible to make an adequate estimation immediately from observations of distribution of islet sections on a histologic slide.Using a large number of alternate serial sections from a monkey pancreas, Thompson (1932) and Thompson and Hussey (1932) made an attempt at analyz ing the density and frequency distribution of the volume of the three-dimensional structures for which they did not consider any appropriate geometrical model. For assessment of the population density they measured the diameter of randomly

These data indicate that GA-FG-CCP, even when submucosal invasion occurs easily, might be of low-grade malignancy as long as it is the chief cell predominant type without other epithelial abnormalities. In addition, GA-FG-CCP might develop despite H. pylori infection or gastric mucosal atrophy.

Continuous monitoring and support for pregnant females may be necessary to address this issue in disaster-affected areas. (Disaster Med Public Health Preparedness. 2017;11:216-226).