Background: The aim of this study to evaluate the outcome of the efficacy of the PRP use to promote wound healing and bone regeneration. Study design: The study was cross sectional being conducted in the department of Dentistry, Bahria University Dental College, Karachi six months from June 2022 to November 2022. Methods: A total number of the participants were 150. The male and female genders were both included who suffered dental surgery. The sample of blood was taken around 55cc by a trained medical expert. After that, blood will be centrifuged to separate the platelet-rich plasma from the remaining components of your blood. For the greatest results, your blood will often be spun two to three times. Results: The age range was 20-60 years and > 61 years old, with an average of 51.1±12.5 years, which indicate highly significant tooth loss at above 61 years old age p<0.005**. The PRP treatment was showing significant improvement in the dental and oral postoperative treatment p<0.005. After postoperative analysis of the participants by the treatment of PRP, which show significant improvement CAL, gingival recession, repair bone defect, stop tooth extraction and root coverage show significant result <0.005** as compared to control group. Conclusions: Following tooth extraction, the application of PRP in the alveolar socket can improve soft tissue healing and favorably affect bone regeneration. Root lengthening, apex closure, and dentin wall thickening were all higher, and they all encourage the rejuvenation of the pulp tissue and further root development. Keywords: Platelet rich plasma, cytokine, growth factor and blood.

Introduction: Anticoagulant therapy is essential for patients with various medical conditions. The use of anticoagulant medications is associated with a prolonged bleeding time. Platelet-rich plasma (PRP) contains a high concentration of platelets. PRP has been used to improve bone and soft tissue regeneration and lessen postoperative complications. Study design: It is a randomized controlled study conducted at DOW International Dental College, Karachi for the duration of six months from August 2022 to January 2023. Material and Methods: The study was done on 40 patients who visited tertiary care unit for duration of six months. There were 6 patients that belonged to the age group 40-50 years. 19 and 15 patients were in the age group 55-60 years and 60-65 years respectively. There were 14 males and 26 females included in our study. There were 72 extractions performed on these patients. Results: It was found that there were 4 patients who reported about hemorrhagic complications. There were two women that had hemorrhage linked to poor placement of platelet gel. One patient reported about hemorrhage related to severe formation of coagulum. Mild bleeding was observed in 13 patients. Conclusion: In conclusion the results of our trial suggest that PRP is a successful anticoagulant therapy that can be used for preventing any post-operative hemorrhagic complication among patients going through dental surgery, as PRP is easy to use, it has low cost and a good placement into residual alveolar bone, therefore it has better outcomes among patients. Keywords: postoperative bleeding, anticoagulant therapy and Platelet-rich plasma.