Diclofenac sodium is included in the class II category based on the biopharmaceutics classification system (BCS), sodium diclofenac has low solubility and high permeability. Low solubility will affect the absorption of drugs in the body because the rate of dissolution will decrease. Polyvinyl Pyrrolidone (PVP) K30 is an inert carrier that dissolves easily in water and can affect the solubility of an active drug substance. To know solid dispersion system increasing dissolution rate of sodium diclofenac by adding variations concentration of PVP K30. Solid dispersion uses a solvent method with variations concentration of PVP K30 1:3, 1:5, 1:7, and 1:9. Test physical properties of solid dispersions using a moisture test and compressibility. Solid dispersion dissolution test using type 2 dissolutions test and determination of concentration using UV-VIS spectrophotometry. Test results were analyzed using One Way ANOVA and continued test. Solid dispersion has a good physical whit moisture percentage not >5% and compressibility not >20%. Solid dispersion of sodium diclofenac with the addition of PVP K30 can increase dissolution rate compared to pure sodium diclofenac (p<0,05) with the highest ratio 1:7. Each comparison has a significant difference (p<0,05) except in ratio 1:9. Solid dispersion of sodium diclofenac with PVP K30 can increase the dissolution rate of pure sodium diclofenac.

Bundung Plant is a efficacious as an antimicrobial. In maximizing its use gel formulation are made from ethanol extract of Bundung Plant. The purpose of this study was to know variations in concentrations HPMC as gel agents against the physical stability. Gel formulation was made in 5 formulas with different HPMC concentrations, namely 1% (F1), 1.5% (F2), 2% (F3), 2.5% (F4) & 3% (F5). Gel formulations are result, each evaluated for physical stability including, organoleptic, pH, homogeneity, viscosity and spread ability. The organoleptis testing, pH, homogeneity and viscosity were analyzed descriptively, while spread ability was analyzed statistically linear regression correlation, one-way ANOVA test. The results of the study showed that variations in the concentration of HPMC did not affect odor, shape, color, pH and homogeneity, but have affect viscosity and spread ability on each gel formulation, and all gel formulation are known to be stable during storage.

Bundung plants (Actinuscirpus Grossus) are widely spread in Borneo and used by society empirically as antimicrobials. Nevertheless, the use of Bundung plants as traditional medicine has not been equipped with convincing data, because there is no research that is related to the plants. In order to the use of the plants accountable, it is necessary to conduct research about phytochemical screening studies and tests the antimicrobial activity of ethanol extract of Bundung plants to staphylococcus aureusandEschericia Coli bacteria. Moreover, extraction does with maceration method. Secondary metabolite groups which are contained in the ethanol extract of Bundung plants were determined qualitatively using several of phytochemical reagents. The result of phytochemical screening test showed that ethanol extract of Bundung plants contains a group of secondary metabolites; namely flavonoid, tannin, saponin, phenolic, steroid and terpenoid. The method that was used to test antimicrobial activity to Staphylococcus aureusandEschericia Coli bacteria was a liquid dilution method with variations in extract concentration of 0,5%, 1%, 2%, 4% and 8% by considering at the clarity of each sample. The result of antimicrobial activity of liquid dilution to bacteria had inhibition at all concentrations and the biggest inhibitory activity was shown at concentration 8% with the clearest level and the MIC grade of the test is at a concentration of 1%. Based on the findings, it can be concluded that ethanol extract of Bundung plants has the potential of activities of an antimicrobial, especially from secondary flavonoid metabolites.

Research of mouthwash formulation and evaluation of bundung plants extract (Actinoscirpus grossus) as an oral antiseptic also has been tested in Streptococcus mutants bacteria by variation in the concentration of extract 2%, 2,5%, 3% and 3,5%, which aims to determine the most ideal formula in physical quality and has the highest antibacterial activity based on an inhibition zone of Streptococcus mutants bacteria in mouthwash formula. The methods used include the step of extraction of Bundung plants, preparation of mouthwash with 4 formula F1 (2%), F2 (2,5%), F3 (3%) and F4 (3,5%) followed by an evaluation that includes organoleptic, pH test, viscosity test and the test of inhibition zone bacteria. The test of inhibition zone bacteria used MHA media with diffusion method. Stability performed on weeks 1, 2, 3, 4, 5, and 6. The result showed variation in the concentration of extract bundung plants in a mouthwash formula has and effect on the diameter of the inhibition zone. But did not have a significant effect on the physical stability properties of the mouthwash formula. Mouthwash formula which has the highest antibacterial activity based on inhibition zone of Streptococcus mutants that is 3,5% contained in formula IV.

Buku Teknologi Penghantaran Obat Terkendali ditulis untuk memberikan dasar-dasar pengetahuan, berupa teori-teori, prinsip-prinsip dan aplikasi pembuatan sediaan yang terkendali atau modifikasi dari tahap awal hingga akhir. Buku ini menjadi dasar dalam rangka pengembangan keilmuan dan penelitian di bidang teknologi sediaan farmasi, khususnya teknologi penghantaran obat yang makin tahun makin maju. Buku ini ditujukan kepada mahasiswa, teman sejawat maupun pembaca lainnya yang ingin mengambil manfaat dari buku ini. Tentu jika mencari kekurangan dari buku ini penulis menjamin akan ditemui banyak kesalahan dan kekurangan, sehingga penulis berharap adanya masukan dan kritik yang membangun demi perbaikan di masa yang akan datang.