Placenta accreta in cesarean section presents problem for an anesthesiologist. It may cause massive bleeding which is usually managed with massive transfusion. In this case series, we report cases of placenta accreta patients undergoing cesarean section managed with massive transfusion. A retrospective case series review of patients diagnosed with placenta accreta undergoing cesarean section with massive bleeding and massive transfusion was conducted between April 2018 and March 2019 in Dr. Moewardi General Hospital using the medical record data. A total of five patients with placenta accreta underwent cesarean section, and massive bleeding as well as massive transfusion was identified. Hysterectomy was performed at the time of cesarean section in all cases. All patients underwent general anesthesia, had central venous catheter, and required massive transfusion. Patients were transferred to the intensive care unit postoperatively. There were no transfusion reactions and maternal death.