Traditional medicine was becoming more popular as a component of complementary and alternative medicine around the world. The ability to provide information on the pharmacological effects of plants requires a thorough understanding of the chemical components found in plants. One of the chemical compounds reported having pharmacological activity was punicalagin. Punicalagin was a polyphenol compound found in Punica granatum, Lafoensia pacari, and genus Terminalia. This review provides information on the pharmacological activities of punicalagin. The bibliographic databases used as the sources of information were PubMed, Google Scholar, and ScienceDirect. The pharmacological activities of punicalagin have been reported as anticancer, antioxidant, hepatoprotective, antimicrobial, antivirus, neuroprotective, antiinflammation, gastroprotective, pre-eclampsia, antidiabetic, and anti hyperlipidemia. Keywords: Punicalagin, Antioxidant, Anticancer, Antivirus.